Defence: Guglielmo Vicario, Destiny Udogie, Cristian Romero, Micky van de Ven, Pedro Porro
There's no question about who starts in goal or across the back four, as Guglielmo Vicario, Destiny Udogie, Cristian Romero, Micky van de Ven, and Pedro Porro have cemented their places in Ange's starting team.
Vicario must be chomping at the bit to face a few early crosses, which will help lift his confidence regarding a perceived weakness. Van de Ven is coming off an almost faultless performance against Everton, while Romero will want a bounce-back match after making a few uncharacteristic mistakes on Merseyside.
Midfield: James Maddison, Yves Bissouma, Pape Sarr
Pape Sarr returned to the club prior to the Everton match and played 26 minutes off the bench. Of the other 18 matches he was available for, he started 15. Sarr was influential in Tottenham's early-season unbeaten run and, now that he's had some time to rest and reacquaint himself with his surroundings, should resume his place in the first 11.
Yves Bissouma had a medical upon returning from the AFCON and was cleared to play. He should start if he's fully fit, which appears to be the case. James Maddison is a staple in the team and, after only two games back, will be looking forward to getting back to pre-injury form.
Rodrigo Bentancur misses out, as Ange owes it to his original starting 11 to see if they can return to the form that saw them go 10 undefeated out of the blocks.
Forwards: Dejan Kulusevski, Richarlison, Brennan Johnson
Richarlison is the top flight's in-form striker, scoring nine goals in the previous eight games. He is tied for seventh in league scoring with 10 Premier League goals. Dejan Kulusevski only played 26 minutes against Everton and was fairly quiet off the bench. Expect Ange to give the Swede an opportunity from kick-off against the Seagulls.
Brennan Johnson started against Everton but was withdrawn after an ineffective 64 minutes. After being introduced at halftime, he scored at home against Brentford in the previous game. Johnson should replace Timo Werner, who has played at least 80 minutes in all three contests after arriving from RB Leipzig. Werner had an assist in his first two matches but was held off the scoresheet at Everton.
Son Heung-min returns to Hotspur Way today after South Korea lost 2-0 to Jordan in the Asian Cup semifinals, but it's too much to expect Tottenham's captain to start after such a taxing three weeks.